Yes, at least according to this study published in the Personality and Social Psychology Bulletin,
physical appearance may play a more important role in personality judgment than previously thought. In addition, our comparison of judgments in the standardized and spontaneous conditions provides the first direct evidence that although some accuracy is possible even without nonverbal expressive aspects of appearance, more traits can be detected and judgments are generally more accurate when nonverbal expressive behavior is available. Overall, the level and breadth of accuracy achieved underline the pervasiveness of personality. As John Irving’s narrator stated, “Things often are as they appear.”
Or, in plain English, if someone looks creepy, odds are they are.
(Special thanks to the friend who sent me the link.)