Not secession – federalism, instead.
See below (*)

The big news this week in Latin America: The four richest Bolivian regions declared autonomy from the Morales government, on the same day as Evo Morales formally received a new draft Constitution.
(*) Clarifying: It’s not secession; it’s federalism
I just received an email from Alek Boyd of VCrisis
First off governors of Santa Cruz, Beni, Pando and Tarija have been democratically elected, as Morales. Ergo that rules out accusations about lacking democratic credentials the official propaganda machine is leveling against them.
Second, they are not seeking independence. Contrary to what the MSM is publishing the autonomic statute in first article states:
“Santa Cruz se convierte en Departamento Autónomo, como expresión de la identidad histórica, la vocación democrática y autonómica del pueblo cruceño, y en ejercicio de su derecho a la autonomía departamental, reforzando la unidad de la República de Bolivia, y los lazos de hermandad entre todos los bolivianos”.
That is to say they are not proposing secession, what they are proposing is self rule in economic, education, tax and resource management issues.
Some of you may think that such a thing amounts to independence from Bolivia, however the prefectos have been very clear in that respect, their proposal is similar to the current system of autonomic regions in Spain.
Third, the issue of autonomic rule was presented to popular vote through referendum. In 4 out of the 9 departments (Santa cruz, Beni Pando and Tarija) the SI option, that is the one supporting autonomy, won. Ergo, said proposal is as democratic as Morales’-driven national constituent assembly from a strictly legal point of view, for if what Morales needed to rewrite the constitution was the approval of “the people” said approval was granted by “the people” to provincial statutes of self rule in those regions.
Fourth, Morales’ constituent proposal has violated procedures, the most striking evidence of it is a) the seat of constituent assembly discussions to get the new charter approved was moved from Sucre to Oruro, so that Morales supporters could get it passed by simple majority [2/3 of votes were never reached], and b) the text approved in Oruro contained originally 408 articles as opposed to the one presented to Morales last Saturday which contains 411 articles. A drafting committee in charge of modifications has introduced 3 new articles which have not been approved
by the constituent assembly, therefore illegal.
Related links in Spanish: Gobierno Departamental de Santa Cruz, and Con los estatutos, prefectos controlan tierras y tributos. From reading this information it’s clear that what the prefectos are after is a federal system like the USA’s.
Special thanks to Alek for clarifying this question. My apologies for my mistake.
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Bolivia set on collision course over autonomy
All the legislation – as well as a separate and especially contentious constitutional provision limiting the size of landholdings – has to be submitted to referendums that are expected to take place early next year.
“I am convinced that we will not retreat a millimetre nor move one step to the side,” Ruben Costas, the governor of Santa Cruz, told tens of thousands of jubilant supporters waving the department’s green and white flags. Mr Costas warned the central government not to send in troops or police. “This is a warning. Do not dare to invade us or militarise us.”
Santa Cruz, Tarija, Beni and Pando departments, which all announced autonomy on Saturday, form a half-moon shape around the solidly pro-government capital and heavily indigenous departments of La Paz, Potosi and Oruro. Two other departments – Cochabamba and Chuquisaca – are unhappy with the new constitution, railroaded through by an emergency session of a constituent assembly eight days ago by pro-government supporters. “The country has taken two different directions,” said an editorial in El Deber, a daily newspaper published in Santa Cruz.
The deputies at the Constituent Assembly approved one version but Evo received a different one; VCrisis has the captures. The first version states that the power comes from the people while the second version stresses the preselection of candidates. Gateway Pundit has more.
At play? Natural gas, which Gazprom is eyeing, along with Brazil and Chile.
Ed Morrissey correctly points out
If these districts can secure themselves against the central government, this could get very, very ugly. Natural gas is their chief export and their resource for hard currency. If the breakaway districts can keep it for themselves and safely export it (mainly to Brazil), they can build a significant war chest while leaving Morales to feed the rest of Bolivia’s poor in the west. That will prompt Morales to march on the east, perhaps assisted by Chavez in Venezuela, and a civil war will almost certainly erupt — and sooner rather than later.
Publius Pundit, Blue Crab Boulevard are blogging on the story, while Marginal Revolution asks, What does Bolivia have to do to make the front page?
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